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Pain Treatment

Effective treatment options for chronic pain are limited to morphine and related drugs that bring with them significant potential side effects, including addiction. In addition, any currently available non-opioid peptide derived pain-treatments (notably conotoxins from cone snails) are relatively short-lived and require intrathecal (spinal) injection. Improvement of the conotoxin approach to peptides having longer half-life alongside IV or oral dosing would amount to a “sea change” in the management of untreatable chronic pain.

The bi-functional parent, soricidin owes its functionality to two separate ion channel modulating components.  The oncolytic domain discussed earlier modulates the TRPV6 ion channel.  Soricidin is a powerful inhibitor of voltage-gated sodium channels and stops nerve transmission.  The paralytic domain has been isolated to the N-series peptides.